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Synfacts 2007(7): 0742-0742
DOI: 10.1055/s-2007-968638
DOI: 10.1055/s-2007-968638
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Uracil Derivatives Using Halogen-Magnesium Exchange
F. Kopp, P. Knochel*
Ludwig-Maximilians-Universität, München, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2007 (online)
Significance
Derivatives of nucleobases like uracil and purin often display a useful biological activity. In this protocol, no preliminary protection of uracil is required, thus the method is one of the operationally most simple ones for the preparation of 5- and 6-substituted uracils. The utility of this method in the synthesis of biologically active molecules is demonstrated by the preparation of antiviral compounds emivirine. The same protocol was successfully applied to the functionalization of 6-iodopurine.