An Enhanced Serum Prolactin Response to TRH in the Presence of GABA Transaminase Inhibition

S. J. Wroe; E. Rimmer; G. Kongola; R. John; R. Henley; A. Richens

doi:10.1055/s-2007-1011798

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Horm Metab Res 1987; 19(6): 278-279
DOI: 10.1055/s-2007-1011798

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An Enhanced Serum Prolactin Response to TRH in the Presence of GABA Transaminase Inhibition

S. J. Wroe¹ , E. Rimmer¹ , G. Kongola¹ , R. John² , R. Henley² , A. Richens¹

¹Departments of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
²Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom

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Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

Patients with epilepsy were found to have an increased 20 minute prolactin response to intravenous TRH stimulation when receiving the GABA-T inhibiting drug vigabatrin. Enhanced GABA activity may either reduce basal prolactin levels whilst allowing a normal pituitary response to TRH stimulation, or may overcome the inhibitory effects of dopamine on pituitary prolactin release.

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