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Horm Metab Res 1987; 19(4): 146-151
DOI: 10.1055/s-2007-1011764
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Thyroidal Modulation of Androgenic Expression in Mice Submandibular Gland

C. A. S. A. Minetti1 , L. B. S. Valle2 , J. H. Romaldini3 , F. Fava-De-Moraes1 , R. M. Oliveira-Filho2
  • 1Departamento de Histologia e Embriologia, Instituto de Ciências Biomédicas, Universidade de São Paulo;, São Paulo, Brasil
  • 2Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brasil
  • 3Hospital do Servidor Público Estadual (Serviço de Endocrinologia), São Paulo, Brasil
Further Information

Publication History

1986

1986

Publication Date:
14 March 2008 (online)

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Summary

We investigated the influence of testes and thyroid gland on the maintenance of biochemical parameters and of [33H]R1881 binding sites of adult mice submandibular gland (SMG). Castration (Cx) performed at beginning of puberty prevented sex-dependent SMG development without interfering with maximal androgen binding capacity. Thyroidectomy (Tx) had strong effects on SMG, mainly by lowering the number of androgen binding sites. All alterations could be fully reverted after treatment with testosterone (5 mg/animal, single dose) or with thyroxine (T4, 250 μg/animal per day during 5 days). The effects of Cx on SMG could be reverted by therapy with testosterone, T4, or with both hormones (testosterone + T4) in a non-synergistic fashion. It is shown the importance of thyroidal activity on the physiological maintenance of androgen receptors in the murine SMG; the role played by thyroid gland seems to be essential for the full expression of the androgen-dependent SMG activity in adult mice.

Key-Words

Submandibular Gland - Mouse - Androgen Receptors - Thyroid Hormones - Androgens

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