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Horm Metab Res 1987; 19(3): 93-95
DOI: 10.1055/s-2007-1011750
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Effect of Propranolol on the Metabolism of Thyroid Hormones

M. J. Dauncey, D. L. Ingram
  • AFRC Institute of Animal Physiology, Babraham, Cambridge, England
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Publikationsverlauf

1986

1986

Publikationsdatum:
14. März 2008 (online)

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Summary

The effect of propranolol on thyroxine (T4) and 3,5′,3′-triiodothyronine (T3 plasma concentrations, fractional disappearance rates (k), metabolic clearance rates (MCR) and catabolic rates has been investigated in young pigs. The animals were examined in the period 18-24 h after feeding. Plasma concentrations of T3 were lower after treatment with propranolol, but T4 was not significantly affected. The k value of T4 was decreased by propranolol but that for T3 was unaffected. The MCR of T4 and the catabolic rates of both hormones were reduced by propranolol. The reduction in metabolic rate after propranolol is thus probably related to its action on thyroid hormone metabolism.

Key-Words

Thyroid - β-Blocker - Diet-Induced Thermogenesis

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