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DOI: 10.1055/s-2006-957529
© Georg Thieme Verlag Stuttgart · New York
(+)-Rhododendrol and epi-Rhododendrin Suppress the NO Production by Activated Macrophages in vivo
Publication History
1997
1998
Publication Date:
04 January 2007 (online)
Abstract
In this study, we investigated the effect of (+)-rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guérin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of l00 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi-Rhododendrin (2), the glucoside of (+)-rhododendrol (1) isolated from the n-BuOH fraction, also suppressed the NO production. As NO is one of the critical mediators in inflammation, these results suggest that (+)-rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti-inflammatory effect of A. nikoense.
Key words
Acer nikoense - Aceraceae - (+)-rhododendrol - epi-rhododendrin - nitric oxide - inflammation - macrophage