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Synfacts 2006(12): 1193-1193  
DOI: 10.1055/s-2006-955591
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ciguatoxin (CTX1B)

Contributor(s): Philip Kocienski
M. Inoue*, K. Miyazaki, Y. Ishihara, A. Tatami, Y. Ohnuma, Y. Kawada, K. Komano, S. Yamashita, N. Lee, M. Hirama*
Tohoku University, Sendai, Japan
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

This awesome synthesis of ciguatoxin features the use of a thioether group to (a) promote linkage of fragments A and B via the formation of an O,S-acetal C and (b) serve as a radical precursor in the cyclization of D to E.