Synthesis of 3-Benzazepinones via Palladium-Catalyzed Hydroamination

Y. Yu; G. A. Stephenson; D. Mitchell

doi:10.1055/s-2006-941972

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Synfacts 2006(8): 0766-0766
DOI: 10.1055/s-2006-941972

Synthesis of Heterocycles

Synthesis of 3-Benzazepinones via Palladium-Catalyzed Hydroamination

Contributor(s): Victor Snieckus, Todd Macklin
Y. Yu, G. A. Stephenson, D. Mitchell*
Eli Lilly and Company, Indianapolis, USA

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Publication History

Publication Date:
21 July 2006 (online)

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Significance

The reported procedure offers a new tactic for the synthesis of 3-benzazepinones via palladium-catalyzed intramolecular hydroamination of acetylenes in modest to good overall yields with high regioselectivity. The precursors are easily prepared by Sonogashira coupling.