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Synfacts 2006(8): 0811-0811
DOI: 10.1055/s-2006-941947
DOI: 10.1055/s-2006-941947
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Ru-TunePhos Catalyzed Enantioselective Hydrogenation of α-Keto Esters
C.-J. Wang, X. Sun, X. Zhang*
The Pennsylvania State University, University Park, USA
Further Information
Publication History
Publication Date:
21 July 2006 (online)
Significance
The α-hydroxy acid motif is a component in many different pharmaceutically useful compounds. Consequently, new methods of synthesis constitute an important challenge. In the present paper the authors use their Cn-TunePhos ligand (J. Org. Chem. 2000, 65, 6223-6226) combined with ruthenium to enantioselectively hydrogenate α-keto esters.