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Planta Med 2001; 67(8): 757-760
DOI: 10.1055/s-2001-18348
Letter

© Georg Thieme Verlag Stuttgart · New York

Hypotensive Effect of Chemical Constituents from Aloe barbadensis

Rubeena Saleem1,*, Shaheen Faizi2 , Bina Shaheen Siddiqui2 , Muhammad Ahmed1 , Syed Ahmed Hussain1 , Aamer Qazi1 , Ahsana Dar2 , Syed Iqbal Ahmad1 , Mahmood Hussain Qazi1 , Shamim Akhtar3 , Syed Nazrul Hasnain3
  • 1 Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan
  • 2 H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
  • 3 Department of Biochemistry, University of Karachi, Pakistan
Further Information

Publication History

December 8, 2000

January 28, 2001

Publication Date:
09 November 2001 (online)

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Abstract

Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).

References

  • 1 Saleem R, Ahmad M, Hussein S A, Qazi A M, Ahmad S I, Qazi M H, Ali M, Faizi S, Akhtar S, Husnain S N. Hypotensive, hypoglycaemic and toxicological studies on the flavonol C-glycoside shamimin from Bombax ceiba .  Planta Medica. 1999;  65 331-4
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Faizi S, Siddiqui B S, Saleem R, Aftab K, Farhana S, Gilani A H. Hypotensive constituents from pods of Moringa oleifera .  Planta Medica. 1998;  64 225-8
    PubMedGoogle Scholar
  • 3 Bhatnagar S S. The Wealth of India. Liliaceae, Aloe. Raw Materials, Vol. 1. Council of Scientific and Industrial Research New Delhi; 1948: 60-2
  • 4 Dymock W, Warden C JH, Hooper D. Pharmacographia Indica, Liliaceae, Aloe vera, vol. 1. The Institute of Health and Tibbi Research, republished under the auspices of Hamdard National Foundation Pakistan; 1890: 447-9
    Google Scholar
  • 5 Farnsworth N R, Bunyapraphatsara N. Thai Medicinal Plants, Aloe vera, Aloe barbadensis . Prachachon Co., Ltd. Bangkok 1992: 35-43 and references cited therein
  • 6 Saleem R, Faizi S, Deeba F, Siddiqui B S, Qazi M H. Anthrones from Aloe barbadensis .  Phytochemistry. 1997;  45 1279-82 and references cited therein
    CrossrefPubMedGoogle Scholar
  • 7 Koo M WL. Aloe vera: Antiulcer and antidiabetic effects.  Phytotherapy Research. 1994;  8 461-4
    PubMedGoogle Scholar
  • 8 Hutter J A, Salman M, Stavinoha W B, Satsangi N, Williams R F, Streeper R T, Weintraub S T. Anti-inflammatory C-glucosyl chromone from Aloe barbadensis .  Journal of Natural Products. 1996;  59 541-3
    CrossrefPubMedGoogle Scholar
  • 9 Heggers J P, Kucukcelebi A, Strabenau C J, Ko F, Broemeling L D, Robson M C. Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin.  Phytotherapy Research. 1995;  9 455-7
    PubMedGoogle Scholar
  • 10 Winters W D, Bouthet C. Polypeptides of Aloe barbadensis Miller.  Phytotherapy Research. 1995;  9 395-400
    PubMedGoogle Scholar
  • 11 Saleem R, Faizi S, Deeba F, Siddiqui B S, Qazi M H. New bisbenzopyran from Aloe barbadensis roots.  Planta Medica. 1997;  63 454-6 and references cited therein
    PubMedGoogle Scholar
  • 12 Yamaguchi I, Mega N, Sanda H. Components of gel of Aloe vera (L.)  Burm. f. Bioscience Biotechnology Biochemistry. 1993;  57 1350-3
    PubMedGoogle Scholar
  • 13 Klopman G, Frierson R M, Herbert S. The structural basis of mutagenicity of chemicals in Salmonella typhimurium. The Gene-Tox data base.  Mutation Research. 1990;  228 1-50; Chem. Abstr. 1990; 112: 173827
    PubMedGoogle Scholar
  • 14 Mueller S O, Eckert I, Lutz W K, Stopper H. Genetoxicity of the laxative drug components emodin, aloeemodin and danthron in mammalian cells: Topoisomerase II mediated?.  Mutation Research. 1990;  371 165-73; Chem. Abstr. 1997; 126: 69936
    PubMedGoogle Scholar
  • 15 Grimaudo S, Tolomeo M, Gancitano R A, D'Alessandro N, Aiello E. Effects of highly purified anthraquinoid compounds from Aloe vera on sensitive and multidrug resistant leukemia cells.  Oncol. Rep.. 1997;  4 341-3; Chem. Abstr. 1997; 126: 194986
    PubMedGoogle Scholar
  • 16 Ishii Y, Tanizawa H, Takino Y. Studies of Aloe V. Mechanism of cathartic effect (4).  Biological & Pharmaceutical Bulletin. 1994;  17 651-3
    PubMedGoogle Scholar
  • 17 Mamitto P, Monti D, Speranza G. Studies on Aloe. Part 6.1 Conformation and absolute configuration of aloins A and B and related 10-C-glucosyl-9-anthrones.  Journal of Chemical Society Perkin Transactions. 1990;  1 1297-300
    PubMedGoogle Scholar
  • 18 Conner J M, Gray A I, Waterman P G, Reynolds T. Novel anthrone anthraquinone dimers from Aloe elgonica .  Journal of Natural Products. 1990;  53 1362-4
    PubMedGoogle Scholar
  • 19 Shin K H, Woo W S, Lim S S, Shim C S, Chung H S, Kennelly E J, Kinghorn A D. Elgonica-dimers A and B, two potent alcohol metabolism inhibitory constituents of Aloe arborescens .  Journal of Natural Products. 1997;  60 1180-2
    CrossrefPubMedGoogle Scholar
  • 20 Okamura N, Hine N, Harada S, Fujioka T, Mihashi K, Miyahara K, Yagi A. Diastereomeric C-glucosylanthrones of Aloe vera leaves.  Phytochemistry. 1997;  45 1519-22
    CrossrefPubMedGoogle Scholar

Dr. Rubeena Saleem

Dr. H.M.I. Institute of Pharmacology and Herbal Sciences

Hamdard University

Karachi-74600

Pakistan

Email: rs127pk@yahoo.com

Fax: +92-21 699-6002, 664-11755

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