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Planta Med 2016; 82(08): 671-689
DOI: 10.1055/s-0042-104800
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Application of MALDI Mass Spectrometry in Natural Products Analysis

Ricardo Silva
1   Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
,
Norberto Peporine Lopes
1   Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
,
Denise Brentan Silva
1   Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
2   Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil
› Author Affiliations
Further Information

Publication History

received 03 May 2015
revised 01 March 2016

accepted 02 March 2016

Publication Date:
28 April 2016 (online)

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Abstract

This article presents the utility of mass spectrometry with a MALDI ionization source in natural products analysis. The advantages and drawbacks of this technique for natural products analyses will be presented and discussed. In addition, the structural determination of secondary metabolites using MALDI-MS/MS will be explored, which can guide MALDI experimental methods and stimulate new research in this area. Finally, several important approaches for MALDI data processing will be discussed.

Key words

MALDI - dereplication - natural products - fragmentation - data processing
 

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