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Synfacts 2009(12): 1409-1409  
DOI: 10.1055/s-0029-1218195
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mukaiyama Aldol Reaction Catalyzed by a MOF-Based Fe³+ Complex

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Toshihiro Watanabe
K. K. Tanabe, S. M. Cohen*
University of California, San Diego, USA
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

A metal-organic framework (MOF) based Fe³+ catalyst was developed and applied to the Mukaiyama aldol reaction. Thus, the MOF-based Fe³+, UMCM-1-AMFesal, was prepared by condensation of MOF composite UMCM-1-NH2 with acid anhydride 1 followed by metalation with Fe(acac)3. The Mukaiyama aldol reaction of aldehydes 5a,b and a silyl ketene acetal 6 was carried out with UMCM-1-AMFesal (0.1 mol% Fe) to give the corresponding β-hydroxy esters in 7011% yield (7a) and 5318% yield (7b). The catalyst was reused twice without loss of catalytic activity.