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Synfacts 2009(10): 1158-1158  
DOI: 10.1055/s-0029-1217945
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

A New Family of Catalysts for 1,3-Dipolar Cycloadditions

Contributor(s): Benjamin List, Kristina Zumbansen
Ł. Weseliñski, P. Stępniak, J. Jurczak*
University of Warsaw and Polish Academy of Science, Warsaw, Poland
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

An enantio- and endo-diastereo­selective 1,3-dipolar cycloaddition of aromatic ­nitrones to (E)-crotonaldehyde and acrolein catalyzed by l-phenylalanine-based catalyst 1 is reported. Different substitutions patterns on the aromatic ring of the nitrone as well as variation in the N-substituents were well tolerated.