Download PDF
Synfacts 2009(10): 1147-1147  
DOI: 10.1055/s-0029-1217884
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd(0)-Catalyzed Intermolecular Arylation of sp³ C-H Bonds

Contributor(s): Paul Knochel, Andrei Gavryushin
M. Wasa, K. M. Engle, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
Further Information

Publication History

Publication Date:
22 September 2009 (online)

    Permissions and Reprints

Significance

Herein, a Pd(0)/PR3-catalyzed intermolecular arylation of β C-H bonds in a range of amide substrates is reported. This reaction provides an interesting and synthetically useful protocol for the catalytic β-arylation of carboxylic acids. Besides, it gives a useful insight into the mechanistic aspects of the development of catalytic sp³-activation methods.