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Synfacts 2009(10): 1065-1065  
DOI: 10.1055/s-0029-1217857
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-BE-43472B

Contributor(s): Philip Kocienski, Indu Dager
K. C. Nicolaou*, Y. H. Lim, J. Becker
The Scripps Research Institute, La Jolla and University of California, San Diego, USA
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

The first total synthesis of both enantiomers of the potent antitumor and antibiotic BE-43472B has been accomplished using a cascade sequence involving Diels-Alder reaction, a hemiketal formation and a nucleophillic ipso substitution.