Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(10): 1125-1125
DOI: 10.1055/s-0029-1217852
DOI: 10.1055/s-0029-1217852
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Nucleophilic Epoxidation of Acyclic Trisubstituted Olefins
B.-F. Sun, R. Hong, Y.-B. Kang, L. Deng*
Brandeis University, Waltham, USA
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
The asymmetric epoxidation of acyclic trisubstituted olefins via a modified Seebach protocol (M. Aoki, D. Seebach Helv. Chim. Acta, 2001, 84, 187) is reported. This reaction was successfully applied to the first asymmetric total synthesis of (-)-plicatic acid (12 steps, 14% overall yield from eugenol).