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Exp Clin Endocrinol Diabetes 1989; 93(2/03): 231-240
DOI: 10.1055/s-0029-1210862
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Streptozotocin Diabetes in Spontaneously Hypertensive Rats

Christel Voss, Vera Moritz2 , K. Hartmann, Irene Herrmann, H. Hahn von Dorsche1 , H. Zühlke
  • 1Institute of Biochemistry, and Institute of Anatomy, Berlin, GDR
  • 2Ernst-Moritz-Arndt-University, Greifswald, GDR, and Central Institute of Cardiovascular Research of the GDR Academy of Sciences, Berlin, GDR
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

The aim of our experiments was to find out to what extent male spontaneously hypertensive (SH) as well as normotensive Wistar-Kyoto (WKY) and Wistar-Schönerlinde (WS) rats developed changes of the endocrine pancreas function in response to streptozotocin (SR). 4 week old WS, WKY and SH rats were given ip. injections of 70 or 100 mg SR/kg and were killed at an age of 8 weeks, after which blood glucose, and in isolated islets, insulin-leakage, insulin secretion and insulin biosynthesis were determined ; histologically the relative volume density of islet tissue was estimated.

The results demonstrate that the intensity of the SR-caused damage to the endocrine pancreas differs considerably in the three strains of rats. The damage increases in the order WS, WKY, SH rats.

These findings are indicative of the role played by genetic predisposition and of an increase in damage to the endocrine pancreas due to hypertension.

Key Words

Diabetes mellitus - Animal model - Rat - Hypertension

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