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Exp Clin Endocrinol Diabetes 1987; 90(6): 365-368
DOI: 10.1055/s-0029-1210713
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effects of Growth Hormone-Releasing Hormone and Corticotropin-Releasing Hormone on the Release of Thyrotropin-Releasing Hormone from the Rat Hypothalamus in Vitro

T. Mitsuma, T. Nogimori, Y. Hirooka
  • Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi/Japan
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Effects of growth hormone-releasing hormone (GRH) and corticotropin-releasing hormone (CRH) on the release of immunoreactive thyrotropin-releasing hormone (ir-TRH) from the rat hypothalamus in vitro were studied. The rat hypothalamus was incubated in medium 199 with 1.0 mg/ml of bacitracin (pH 7.4) for 20 min. The amount of ir-TRH release into the medium was measured by radioimmunoassay. The ir-TRH release from the rat hypothalamus was inhibited significantly in a dose-related manner with the addition of GRH or CRH.

These findings suggest that GRH and CRH inhibit ir-TRH release from the rat hypothalamus in vitro.

Key words

Thyrotropin-releasing hormone - Growth hormone-releasing hormone - Corticotropin-releasing hormone - Hypothalamus

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