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Exp Clin Endocrinol Diabetes 1987; 90(6): 324-330
DOI: 10.1055/s-0029-1210708
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Effect of High Parathyroid Hormone Concentration on Calcitonin in Patients with Primary Hyperparathyroidism2)

N. Kübler, U. Krause, P. K. Wagner1 , J. Beyer, M. Rothmund1
  • Department of Endocrinology (Head: Prof. Dr. med. J. Beyer), Johannes Gutenberg-University, Mainz
  • 1Department of Surgery (Head: Prof. Dr. med. M. Rothmund), Philipps-University, Marburg/FRG
2) This work was supported by Deutsche Forschungsgemeinschaft (Ro 519/2).
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Publikationsverlauf

1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

Serum calcitonin (CT), parathyroid hormone (PTH), and calcium levels were measured in 23 patients with primary hyperparathyroidism. PTH was determined by a midregion (M-RIA) and a carboxyl-terminal (C-RIA) specific PTH-RIA. Only 2 patients had elevated CT levels. In contrast to the findings in 46 healthy controls, the CT levels did not correlate with calcium levels. Patients who had the highest iPTH values showed a negative correlation between CT and iPTH (M-RIA (n = 7): R = −1.0000, p < 0.001; C-RIA (n = 13): R = −0.5604, p < 0.05). The results of the C-RIA were subtracted from those of the M-RIA. In 12 patients with the highest levels of intact PTH (M-RIA — C-RIA), serum PTH concentration was inversely correlated with serum CT concentration (R = −0.7343, p < 0.01). In the same patients a negative correlation between CT and calcium was found (R = −0.6783, p < 0.02).

These findings suggest that high PTH levels may have a direct suppressive effect on CT concentration and this may be, at least in part, responsible for failure of CT concentrations to rise in many patients with primary hyperparathyroidism.

Key words

Calcitonin - Parathyroid hormore - Primary hyperparathyroidism

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