Exp Clin Endocrinol Diabetes 1987; 90(4): 107-112
DOI: 10.1055/s-0029-1210679
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Nuclear and cytosol Androgen Receptor in Androgen Dependent Dermatoses in Female Patients

Jolanta B. Schmidt
  • Department of Dermatology II (Head.: Prof Dr. G. Niebauer), University of Vienna, Vienna/Austria
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

Summary

Determination of cytosol and nuclear androgen receptor (AR) was performed in females with androgen dependent dermatoses. 34 patients with acne, hirsutism and androgenetic alopecia were punch biopsied on day 21 of the menstrual cycle under local anesthesia within correspondent predilection sites. The tissue was snap frozen in liquid nitrogen and stored until receptor assays were performed. Overall evaluation of both, cytosol and/or nuclear AR was positive in 76% of all cases. In 86% of (10 out of 14) females with androgenetic alopecia, in 80% (8 out of 10) of patients with acne and 60% (6 out of 10) of hirsute females cytosol and/or nuclear AR were positive. No significant differences of cytosol androgen receptor levels became evident between the dermatoses. In contrast, nuclear androgen receptor levels showed a trend towards distinct differences with highest levels in hirsutism, followed by androgenetic alopecia and acne. Androgen stimulability thus seems to be superior in the first and minor in the latter. comparison with previous studies on cytosol androgen receptor in androgen dependent dermatoses shows significantly higher number of positive results by additive nuclear receptor determination. Additional nuclear androgen receptor assay, thus gives a more complete picture of local hormone action.

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