Download PDF
Exp Clin Endocrinol Diabetes 1987; 90(4): 46-50
DOI: 10.1055/s-0029-1210671
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Induction of a Diabetes-Like Syndrom by Cyclosporine in Wistar Rats and its Reversibility after Drug Withdrawal

H. J. Hahn, Christiane Kauert, G. Kotzke
  • Central Institute of Diabetes, Research and Treatment (Director: OMR Prof. Dr. H. Bibergeil), Karlsburg/GDR
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Cyclosporin A exerts dose- and time-related toxic effects on pancreatic B-cells. We investigated the reversibility of Cyclosporin A-induced alterations on glucose tolerance and pancreatic insulin content in Wistar rats either still normoglycaemic or animals being hyperglycaemic after different treatment periods. Both groups of animals either formerly normoglycaemic but glucose intolerant or hyperglycaemic normalized glucose intolerance, glycaemia and reenhanced pancreatic insulin content. This demonstrates that also hyperglycaemic animals are able to recover spontaneously from a diabetes-like state.

Key words

Cyclosporin A - Glucose Intolerance - Hyperglycaemia - Pancreatic Insulin Content - Reversibility

      >