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Exp Clin Endocrinol Diabetes 1987; 90(4): 26-36
DOI: 10.1055/s-0029-1210669
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Influence of Desmethylimipramine on the Hypothalamic and Neurohypophysial Vasopressin Content in Pinealectomized Male Rats1)

Mahlena Juszczak, J. W. Guzek
  • Department of Pathophysiology (Head: Prof. Dr. hab. med. J. W. Guzek), Institute of Pathology (Head: Prof. Dr. hab. med. Z. Torzecki), School of Medicine, Łodz/Poland
1) Conducted under contract No. 06.03.3.5. with the Polish Academy of Sciences.
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

The effect of desmethylimipramine (DMI) on the hypothalamic and neurohypophysial vasopressin content was investigated in normal and pinealectomized male rats. The vasopressor activity of the hypothalamus and neurohypophysis was bioassayed by the method of Dekanski (1952).

A single i.c.v. injection of DMI (20 μg; dissolved in 10 μl of normal saline) decreased vasopressin content in the neurohypophysis of non-operated and sham-operated animals. In pinealectomized rats the vasopressin content in the neurohypophysis diminished and was not modified by an i.c.v. DMI injection.

Repeated treatment with DMI (i.p. ; 10 mg/kg, twice a day over five days) resulted in a distinct increase of the hypothalamic and neurohypophysial vasopressin in both normal and pinealectomized rats.

Key words

Desipramine - Vasopressin - Pinealectomy

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