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Exp Clin Endocrinol Diabetes 1987; 89(3): 340-344
DOI: 10.1055/s-0029-1210660
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Defect of Cellular Suppressor Function in the Pathogenesis of Type I Diabetes Mellitus1)

D. Lohmann, E. Lampeter, J. Krug, A. Pachi, B. Bierwolf, H. J. Verlohren
  • City Hospital of Leipzig, Leipzig/GDR
1) This study was supported by the research project HFR M22 of the Ministry of Health of the GDR.
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

In 29 out of 30 type I diabetic patients the peripheral blood lymphocytes induced an insulin release from isolated rat islets which was regarded as a cytotoxic effect, i.e. a model of beta cell destruction in diabetes mellitus. In 11 out of 12 cases, this effect was inhibited by the in vitro addition of lymphocytes from healthy probands. Thus the activation of cytotoxic T-cells demonstrated by this observation might be the consequence of a defect in suppressor cell function. Consequently, the transfusion in vivo of lymphocytes from healthy probands strongly reduced the cytotoxic reaction of the lymphocytes from newly diagnosed diabetic recipients in vitro.

Key words

Type I diabetes mellitus - Cell-mediated cytotoxicity - Defect of suppressor function - Lymphocyte transfusion

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