Effect of lodination on the Biological Activity of Insulin

B. Lambert; B. Ch J. Sutter; C. I. Jacquemin

doi:10.1055/s-0028-1094089

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Horm Metab Res 1972; 4(3): 149-151
DOI: 10.1055/s-0028-1094089

Originals

Effect of lodination on the Biological Activity of Insulin

B. Lambert , B. Ch. J. Sutter , CI. Jacquemin

Laboratoire de Biochimie, Laboratoire de Physiologie animale et Centre de Biologie et de Biochimie du Developpement de la Faculté des Sciences de Reims, France

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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The preparation of pure ¹²⁵I-monoiodoinsulin is described. This iodohormone has lost its capacity to stimulate the glucose uptake by rat diaphragm, nevertheless it binds to the plasmatic receptors and competes with unlabeled insulin.

Key words

Monoiodoinsulin - Bioactivity - Binding Constants - Inhibitory Effect