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Synfacts 2009(5): 0546-0546
DOI: 10.1055/s-0028-1088180
DOI: 10.1055/s-0028-1088180
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Iron-Catalyzed Negishi Coupling of Benzyl Halides and Phosphates
R. B. Bedford*, M. Huwe, M. C. Wilkinson
University of Bristol and GlaxoSmithKline, Stevenage, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
Diarylzinc compounds can be efficiently cross-coupled with benzylic chlorides, bromides or phosphates in the presence of iron/diphosphine complexes as catalysts. The reaction gives excellent yields of diarylmethanes also bearing labile functions. This is one of the first reports demonstrating high selectivity of different phosphine ligands for an iron-catalyzed reaction.