RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2009(5): 0465-0465
DOI: 10.1055/s-0028-1088179
DOI: 10.1055/s-0028-1088179
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Wasabidienones B1 and B0
L. Pouységu, M. Marguerit, J. Gagnepain, G. Lyvinec, A. J. Eatherton, S. Quideau*
Université de Bordeaux, Pessac, France and GlaxoSmithKline, Harlow, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
Wasabidienones B0 and B1 were isolated from Phoma wasabiae Yokogi, a fungus causing widespread destruction of rape, cabbage and wasabi. The o-quinol framework is rather unusual in nature, since most of these compounds readily undergo Diels-Alder dimerization. The focal step of this synthesis is an oxidative dearomatization of the phenol F using the oxidant SIBX, a commercial, stabilized, non-explosive form of IBX.