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Synfacts 2009(1): 0049-0049
DOI: 10.1055/s-0028-1087435
DOI: 10.1055/s-0028-1087435
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Construction of Aryl-Substituted Quaternary Centers by Conjugate Addition
C. Hawner, K. Li, V. Cirriez, A. Alexakis*
University of Geneva, Switzerland
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Dezember 2008 (online)
Significance
The authors have developed the copper-catalyzed asymmetric conjugate addition (ACA) of arylaluminum reagents to enones leading to the chiral aryl-substituted quaternary centers with good to excellent yields and in excellent enantioselectivities. The desired arylaluminum reagents can be easily prepared from the corresponding aryl iodides through an I/Li exchange followed by Li/Al transmetalation, and the resulting arylaluminum reagent can be used without any separation of the resulting insoluble LiCl.