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Horm Metab Res 2023; 55(11): 758-764
DOI: 10.1055/a-2183-8683
Original Article: Endocrine Care

The Associations of Maternal Blood Hemoglobin and Serum Triglyceride Levels and the Risk of Preterm Delivery

Xia Song
1   Gynecology, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China
,
Jiujing Lin
2   School of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
,
Xiaoxiao Dong
3   Shandong Provincial Maternal and Child Health Care Hospital, Shandong, Jinan, China
,
Mengyun Li
1   Gynecology, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China
,
Xiangsheng Xue
2   School of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
,
Chenyang Hou
4   Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
,
Huichen Yao
5   Cardiology Department, The Third Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
,
Qingzhi Hou
2   School of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
› Author Affiliations Fundings Academic Promotion Program in the School of Public Health and Health Management — GW202212 Shandong First Medical University Science and Education Integration talents academic promotion plan funds — 922/001003088002 Provincial Innovation project for college students — S202110439082 Shandong Province Medical and health Project — 202102040656
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Abstract

The abnormal hemoglobin (HGB) and serum lipid concentrations during pregnancy will increase the risk of preterm delivery. Our study aimed to explore the correlation between prenatal HGB and serum lipid levels and preterm delivery. We enrolled 215 mother-infant pairs in a pilot cohort study. The logistic regression model and Restricted Cubic Spline model (RCS) were used to investigate the levels of prenatal blood HGB and serum lipid such as triglyceride (TG), total cholesterol, high-density lipoprotein, low density lipoprotein and preterm delivery. The results showed that moderate levels of prenatal blood HGB (OR=0.28; 95%CI: 0.10, 0.75, p-trend=0.018) and high level of serum TG (OR=0.29; 95%CI: 0.10, 0.84, p-trend=0.022) level were negatively associated with the risk of preterm delivery. The joint effect results showed that compared with lower level of prenatal blood HGB (≤123.13 g/l) and TG (≤3.7 mmol/l), we found that high levels prenatal blood HGB and serum TG (OR=0.32, 95%CI: 0.12, 0.89) had a negative association with the risk of preterm delivery. Moreover, prenatal blood HGB and serum TG levels had negative linear dose-effect relationships with the risk of preterm delivery in overall and girl group (p<0.05). Moderate levels of prenatal blood HGB and high level of serum TG were negatively associated with the risk of preterm delivery. The joint effect of high levels prenatal HGB and prenatal serum TG in the normal range were negatively correlated with preterm delivery. Moreover, the underlying mechanisms should be clarified in future studies.

Key words

hemoglobin - triglyceride - preterm delivery - joint effect

Supplementary Material



Publication History

Received: 06 April 2023

Accepted after revision: 26 September 2023

Article published online:
30 October 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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