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CC BY-NC-ND 4.0 · Horm Metab Res 2023; 55(09): 585-591
DOI: 10.1055/a-2142-4811
Original Article: Endocrine Care

Factors of Central Lymph Node Metastasis in Papillary Thyroid Cancer Based on C-TIRADS Analysis

Weijun Huang‡
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Deli Chen‡
2   Zhuhai Campus, Zunyi Medical University, Zunyi, China
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Minying Zhong
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Jieyi Ye
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Zhiyuan Zhi
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Yanyan Xiao
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
,
Yuan Zhong
1   Department of Ultrasound, First People’s Hospital of Foshan, Foshan, China
› Author Affiliations
Funding Information Medical Scientific Research Foundation of Guangdong Province of China — B2021374; Project of Foshan “Fourteen Five” Medicine High-level Key Specialty Construction — FSGSP145037; Medical Scientific Research Foundation of Guangdong Province of China. — A2023502
› Further Information
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Correction: Factors of Central Lymph Node Metastasis in Papillary Thyroid Cancer Based on C-TIRADS AnalysisHorm Metab Res 2023; 55(09): e5-e5
DOI: 10.1055/a-2177-1891

Abstract

To study risk factors for central lymph node metastasis (CLNM) in papillary thyroid cancer (PTC) using the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS). We retrospectively analysed patients who underwent PTC surgery and central lymph node dissection at First People’s Hospital of Foshan City. The clinical and ultrasonic data of the patients from 1150 cases were analysed by multivariate regression to evaluate the correlation between grayscale ultrasound (US) features, C-TIRADS score, and the classification of thyroid nodules and CLNM of PTCs. The C-TIRADS score was 3.0±1.0 in the CLNM group, which was higher than that in the non-CLNM group (p<0.001). Sex (male) (OR=1.586, 95% CI 1.232–2.042, p<0.001), age (≤45 years) (OR=1.508, 95% CI 1.184–1.919, p=0.001), location of nodes (lower pole) (OR=2.193, 95% CI 1.519–3.166, p<0.001), number (multifocal) (OR=2.204, 95% CI 1.227–2.378, p<0.001), microcalcification (OR=1.610, 95% CI 2.225–4.434, p=0.002), extrathyroidal extension (OR=2.204, 95% CI 1.941–3.843, p<0.001), maximum diameter of nodule (≥20 mm) (OR=3.211, 95% CI 2.337–4.411, p<0.001), and C-TIRADS score (OR=1.356, 95% CI 1.204–1.527, p<0.001) were PTC in independent risk factors for CLNM. The C-TIRADS score of PTC combined with the location, number, size, and ultrasound features of the lesion and the patient’s sex and age are important in predicting whether they present with CLNM and provide a reference basis for the clinical formulation of a reasonable surgical treatment plan.

Key words

papillary thyroid cancer - central lymph node metastasis - ultrasound - china thyroid imaging reporting and data system


Publication History

Received: 04 March 2023
Received: 17 July 2023

Accepted after revision: 27 July 2023

Accepted Manuscript online:
27 July 2023

Article published online:
07 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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