Dtsch Med Wochenschr 2024; 149(06): 298-302
DOI: 10.1055/a-2113-0830
Klinischer Fortschritt
Geriatrie

Vorhofflimmern im Alter – die geriatrische Perspektive

Atrial fibrillation in the elderly - the geriatric perspective
Markus Gosch
1   Gerontologie und Geriatrie, Paracelsus Medizinische Privatuniversitat - Nurnberg, Nurnberg, Germany (Ringgold ID: RIN470426)
› Author Affiliations

Was ist neu?

Was macht geriatrische Patienten besonders? Bei geriatrischen Patienten sind verschiedene Aspekte zu bedenken. Der überwiegende Teil der pharmakologischen Therapien fällt in den Bereich der Prävention, z.B. die Antikoagulation bei Vorhofflimmern. Dies bedeutet, dass wir ein bestehendes Risiko reduzieren wollen und dabei andere Risiken in Kauf nehmen. Bei alten und hochaltrigen Patienten stellt sich somit immer die Frage: Erlebt der Patient den klinischen Benefit der Therapie noch?

Frequenz- vs. Rhythmuskontrolle Als Folge der positiven Daten zur Ablation hat sich der Fokus auf die Rhythmuskontrolle gelegt. Mittel der Wahl ist die Pulmonalvenen-Isolation. Auch ältere Patienten können von einer Ablation profitieren.

Vorhofflimmern und orale Antikoagulation Die orale Antikoagulation bleibt essenzieller Bestandteil der pharmakologischen Therapie bei Vorhofflimmern. Die Behandlung geriatrischer Patienten erfordert einen individuellen Behandlungsansatz, welcher auf den aktuellen Leitlinien und ergänzenden Hilfsmitteln basieren sollte. Die Beurteilung der Funktionalität sollte in der Therapie und der Therapiezielplanung Berücksichtigung finden.

Vorhofflimmern und kognitive Beeinträchtigung Hinweise auf einen Zusammenhang zwischen Vorhofflimmern und Kognition gibt es schon länger. In einer großen prospektiven Studie mit einem langen Beobachtungszeitraum konnte in der Gruppe der Personen mit Vorhofflimmern eine Zunahme der Demenz an sich, sowie auch der Subgruppen (Mild Cognitive Impairment, Mb. Alzheimer, vaskuläre Demenz) gezeigt werden.

Abstract

Atrial fibrillation is the most common cardiac arrhythmia in older adults. As a result of the positive data on ablation, the focus has shifted to rhythm control. The method of choice is pulmonary vein isolation. Even older patients may benefit from ablation. Oral anticoagulation remains an essential component of pharmacological therapy for atrial fibrillation. Older adults require an individualised treatment approach, which should be based on current guidelines and complementary tools. The assessment of functionality should be taken into account in therapy and goal planning.



Publication History

Article published online:
27 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Arnold AM, Psaty BM, Kuller LH. et al. Incidence of cardiovascular disease in older Americans: the cardiovascular health study. J Am Geriatr Soc 2005; 53: 211-218
  • 2 Fried LP, Tangen CM, Walston J. et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-56
  • 3 Leendertse AJ, Egberts AC, Stoker LJ. et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med 2008; 168: 1890-1896
  • 4 Howard RL, Avery AJ, Slavenburg S. et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol 2007; 63: 136-147
  • 5 Laroche ML, Charmes JP, Nouaille Y. et al. Is inappropriate medication use a major cause of adverse drug reactions in the elderly?. Br J Clin Pharmacol 2007; 63: 177-186
  • 6 Gosch MHH. Pharmakotherapie. In: Pantel S, Bollheimer C, Sieber C, Kruse A. Praxishandbuch Altersmedizin. Stuttgart: Kohlhammer; 2014: 642-650
  • 7 Chudiak A, Uchmanowicz I, Mazur G. Relation between cognitive impairment and treatment adherence in elderly hypertensive patients. Clin Interv Aging 2018; 13: 1409-1418
  • 8 Chung SC, Lai A, Lip GYH. et al. Impact of anti-arrhythmic drugs and catheter ablation on the survival of patients with atrial fibrillation: a population study based on 199 433 new-onset atrial fibrillation patients in the UK. Europace 2023; 25: 351-359
  • 9 Andrade JG, Wells GA, Deyell MW. et al. Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. N Engl J Med 2021; 384: 305-315
  • 10 Kirchhof P, Camm AJ, Goette A. et al. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med 2020; 383: 1305-1316
  • 11 Rillig A, Borof K, Breithardt G. et al. Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden. Circulation 2022; 146: 836-847
  • 12 Parkash R, Wells GA, Rouleau J. et al. Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients With Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial. Circulation 2022; 145: 1693-1704
  • 13 Boehmer AA, Rothe M, Zezyk C. et al. Persistent Atrial Fibrillation in Elderly Patients: Limited Efficacy of Pulmonary Vein Isolation. J Clin Med 2022; 11: 6070
  • 14 Al-Kaisey AM, Parameswaran R, Bryant C. et al. Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress: A Randomized Clinical Trial. JAMA 2023; 330: 925-933
  • 15 Kirchhof P, Benussi S, Kotecha D. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2016; 37: 2893-2962
  • 16 Hylek EM, Evans-Molina C, Shea C. et al. Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation. Circulation 2007; 115: 2689-2696
  • 17 Friberg L, Rosenqvist M, Lip GY. Net clinical benefit of warfarin in patients with atrial fibrillation: a report from the Swedish atrial fibrillation cohort study. Circulation 2012; 125: 2298-2307
  • 18 Man-Son-Hing M, Nichol G, Lau A. et al. Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Arch Intern Med 1999; 159: 677-685
  • 19 Donze J, Rodondi N, Waeber G. et al. Scores to predict major bleeding risk during oral anticoagulation therapy: a prospective validation study. Am J Med 2012; 125: 1095-1102
  • 20 Gosch M, Iglseder B, Heppner HJ. Falls and dementia are not contraindications for anticoagulation in older adults with atrial fibrillation. Z Gerontol Geriatr 2016; 49: 458-459
  • 21 Bahrmann P, Harms F, Schambeck CM. et al. New oral anticoagulants for prophylaxis of stroke. Results of an expert conference on practical use in geriatric patients. Z Gerontol Geriatr 2016; 49: 216-226
  • 22 Feeney JM, Santone E, DiFiori M. et al. Compared to warfarin, direct oral anticoagulants are associated with lower mortality in patients with blunt traumatic intracranial hemorrhage: A TQIP study. J Trauma Acute Care Surg 2016; 81: 843-848
  • 23 Feeney JM, Neulander M, DiFiori M. et al. Direct oral anticoagulants compared with warfarin in patients with severe blunt trauma. Injury 2017; 48: 47-50
  • 24 Larsen TB, Skjoth F, Nielsen PB. et al. Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ 2016; 353: i3189
  • 25 Alonso A, Knopman DS, Gottesman RF. et al. Correlates of Dementia and Mild Cognitive Impairment in Patients With Atrial Fibrillation: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). J Am Heart Assoc 2017; 6: e006014
  • 26 Dietzel J, Haeusler KG, Endres M. Does atrial fibrillation cause cognitive decline and dementia?. Europace 2018; 20: 408-419
  • 27 Proietti M, Recchia A, Riva E. et al. Relationship between atrial fibrillation and cognitive decline in individuals aged 80 and older. Eur J Intern Med 2017; 46: 6-10
  • 28 Bunch TJ, Crandall BG, Weiss JP. et al. Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation. J Cardiovasc Electrophysiol 2011; 22: 839-845